Alterations of Sympathetic Vascular Tone in Arteries

We are jumping into a very complex and in-depth discussion of something that may be a little confusing so I will try to go slow and not go off on a tangent. As we start the most important thing we need to talk about is a little bit of the anatomy and how the body works. I'm sure you know that tone and texture of the inside of your arteries and vein are very important. The veins are on the lower pressure side and the arteries are on the high pressure side. The veins are very distensible so they can act to store large amounts of blood in a time of relaxation and contract and push the blood into the arterial side when the heart needs to increase cardiac output. The arteries are relaxed or constricted  based certain physiological needs to that tissue. If a tissue needs more blood it constricts arteries to other areas that do not need blood at that certain time. Hormones also play important roll in this system as well, hormones like cortisol causes an activation of the sympathetic system. When the sympathetic are active under either hormonal or neural control the arteries increases their muscle tone to slow the blood flow from organs which are not used in a period of distress or intense activity. This is how the system should work properly.

The way this system works in a lot of people is problematic, first people are stressed, stress causes the release of cortisol, the release of cortisol causes the increase of the sympathetic nerve system systemically. The activation of the sympathetic nervous system causes a decrease of lumen diameter, thus increasing overall blood pressure. You see how this is a slippery slope of how the body works. I will say that arterial lumen pressure is inversely proportional to diameter, meaning as the lumen gets small pressure goes up. There are two ways the body can increase blood pressure, increase the cardiac output, and decrease artery diameter. The only way the heart can increase cardiac output or work is to do two things, first increase the force of contraction of the ventricles and increase the amount of blood pumped by the ventricles. So if you are always running on your sympathetic system invariably you will have a higher blood pressure, but how do we fix this?

With the sympathetic nervous system on overall you must break the brain-body communication so to speak we must reboot the system but how? How about we preform something that going to overload the whole system to restart, something call afferent barrage, now I'm using afferent barrage very loosely. When I use this term it is in the context of applying numerous sensory stimuli to a certain area in the body. It's possible to reset the system from sensory input. When spinal manipulation is applied to a segment, it's creating many synaptic connection, which could reset the system, of course more evidence is needed to fully valid the effectiveness. The afferent input could in turn lower the force of heart contraction, reduce the amount of blood pumped for contraction, and dilate the arterial lumen. There have been studies that show spinal manipulation could decrease blood pressure but they have some decrease of bias. However, it's exciting to see the possibility of an external stimuli causing a sympathetic change.            

Do You Really Understand Your Medication?

Do you know the effects of your medication and why you are taking it? Many people don't and they are not explained the risks or benefits of the medication from their doctor. Better yet does the doctor understand the medication he/she is prescribing to you. Has your doctor done extensive research on the medication or is he/she only going by what the pharmaceutical companies are telling him/her? Are the pharmaceutical companies being truthful in what they are telling a doctor? Do the pharmaceutical companies care about you getting better or keeping you sick? They are in a business and that business is making money. Americans are a very small portion of the world population but we take fifty percent of the drugs, why?

In this day and age it is very important to understand how big pharm has ushered their evil head into main street. Big pharm has been caught red handed, bribing doctor, withholding evidence, withhold risk, and misleading the public in what their drugs do and don't do. The pharmaceutical companies have been fined billions of dollars for misrepresenting drugs and hiding risk and outcome. They have literally been fined billions of dollars in just one lawsuit and they chalk this up to the cost of doing business. Thousands of people of have died because of pharmaceutical companies are not telling the truth. People dying and countless lawsuits is just the cost of doing business to them. They are a business they do not care if you live, die, get better or stay sick, as long as you are buying their drug and they are making money off you.

This example caught my eye and I felt like I needed to share it, while of course drugs are very important I am against the way drugs are used in this county, all to the benefit of a company and at the expense of the general public. Merck recently paid a law suit in the amount of $688 million dollars for withholding evidence about one of their cholesterol drugs named Vytorin. They did a study called the Enhanced study which was a double blind randomized control trail in which they were testing if Vytorin decreased the risk of atherosclerosis by decreasing thickness of the carotid artery. It was found in 2006, that indeed Vytorin did not reduce the risk of atherosclerosis but actually worsen the carotid artery thus increase the risk of atherosclerosis and heart disease. So in essence the drug was actually making patients more likely to have a heart attack. The drug did lower cholesterol but did not stop atherosclerosis which is why you want your cholesterol to be low in the first place.

So with Merck knowing that their drug was an epic failure and did harm to a certain extend, do you know who they told? Nobody! This was keep quiet while Merck made over 5 billion dollars from 2006-2008 off this drug. Once the release of this information in 2008 that their drug was a failure and did not work doctors continued to prescribe it, either not caring or not knowing (which is worst), making Merck in 2012 4.4 billion dollars from Vytorin. It needs to be noted that statin drugs (cholesterol lowering drugs) which include Vytorin and other drugs have never been shown to decrease atherosclerosis, or decrease the risk of stoke and heart attacks. Cholesterol-lowering medications have never been shown to prevent a heart attack.  The only benefit these drugs have shown to do is to lower the risk of mortality by about 1% in patients who have already had a cardiovascular event. So why are we taking these drugs. Lowering your cholesterol does not equal lower risk of cardiovascular events.

Please be leery of what you are prescribed and question who has your best interest in mind. Remember the best medicine on earth is eating right, exercising and talking care of your body. Your Plano Chiropractors at Twisted Spine and Joint Center want to help you achieve your health and wellness goals whatever they may be. Yours in great health!